1-Hydroxybenzotriazole and 1-hydroxypyridine-2-thione were incorporated as ligands with the cluster Ru3(CO)10(NCMe)2 to give [(μ-H)Ru3(CO)10(μ2-2,3-η;2-NNN(O)C6H4)] and [(μ-H)Ru3(CO)9(μ2-η;1 : η;2-C5H4N(O)S)], respectively. Irradiation of these two new triruthenium metal clusters individually with 350 nm UV light in a phosphate buffer (pH 6.0) containing form I DNA resulted in single-strand cleavage. Cluster [(μ-H)Ru3(CO)10(μ2-2,3-η;2-NNN(O)C6H4)] was also found to bind to calf thymus DNA upon UV irradiation.
How to translate text using browser tools
1 May 2002
New Triruthenium Clusters as Photoinduced DNA-binding and Cleaving Agents
Jih Ru Hwu,
Kuang-Lieh Lu,
Sheng-Fa Yu,
Lee-Ju Yu,
Sudalaiandi Kumaresan,
Kuan-Jiun Lin,
Shwu-Chen Tsay
ACCESS THE FULL ARTICLE
It is not available for individual sale.
This article is only available to subscribers.
It is not available for individual sale.
It is not available for individual sale.
Photochemistry and Photobiology
Vol. 75 • No. 5
May 2002
Vol. 75 • No. 5
May 2002
